The Vampire's Assistant is the second instalment in the saga of Darren Shan, which began with Cirque du Freak. Then, Darren made the difficult decision to become a half-vampire to save his best mate Steve Leopard's life. Now, he must leave his friends and family behind as he travels cross-country with the vampire Mr Crepsley and the Cirque du Freak. Early on, Darren dispels the vampire myth in his typically facetious fashion:
Crosses and holy water didn't hurt us. All garlic did was give us bad breath ... A stake through the heart would kill us, of course, but so would a bullet or a knife or electricity ... We were tougher to kill than normal people, but we weren't indestructible.